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Psychedelics Alcohol and Drug Foundation Canadian psychiatrists Humphrey Osmond and Abram Hoffer considered LSD for the treatment of alcoholism to be especially promising. Indeed, there were a number of publications suggesting that psychedelics could be useful in treating substance abuse (Chwelos et al., 1959; Smart et al., 1966; Hollister et al., 1969; Savage and McCabe, 1973). Unfortunately, early investigators did not employ rigorous clinical methods such as randomized controlled trials, outcome measures, and treatment settings, and thus those studies did not provide definitive results. Abuzzahab and Anderson reviewed studies of 1100 alcoholic patients treated with LSD in the period from 1953 to 1969 and came to a similar conclusion; however, they did find reports of improvement at 10 months for 75% of patients who received a single dose of LSD compared with only 44% of controls. For patients who received multiple doses of LSD, 58% were “improved” compared with 54% of the controls